TIME
from TIssue to Molecular mechanisms of restenosis
after peripheral Endovascular interventions
NEWS
January 2022
New publication online!
Enjoy our new findings about hemodynamic alterations caused by stenting design and interventional choice in diseased femoral arteries, published in Computers in Biology and Medicine!
November 2021
New publication online!
Read and discover more about Agent-Based Modelling of Vascular Adaptation in our new review article in Frontiers in Bioengineering and Biotechnology!
October 2021
New publication online!
Find our new research product on the 3D modelling of the drug-coated balloon treatment for calcified human superficial femoral arteries, availble online at:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256783
July 2021
TIME booth at ESB2021!
TIME was present at the "project corner" during the ESB2021 conference. Our team got the chance to present the overall project, openly discussing about the main as well as side projects. Watch the brief video about out team, goals and research products!
Anna Corti wins at ESB2021!
Our Anna Corti has been awarded at the ESB2021 conference (https://esbiomech.org/conference/esb2021/) with the ESB Student Award, for her presentation entitled "A finite element – agent-based coupled model of restenosis: linking tissue damage to cellular dynamics", within the TIME project.
June 2021
TIME presented at SB3C2021!
During the SB3C 2021 conference (https://sb3c.org/),
Anna Corti and Monika Colombo presented their work part of the TIME project to the community!
Congrats, Dr. Colombo!
Our warmest congratulations to Dr. Colombo Monika, who brilliantly defended her PhD thesis entitle "Impact of fluid dynamics and drug transport on restenosis in femoral arteries after endovascular treatment"!
April 2021
New publication online!
Find our new research product on the analysis of the restenosis progression in human superficial femoral arteries, availble online at:
https://link.springer.com/article/10.1007/s10439-021-02776-1
TIME presented at SimWorld
Anna Corti presented her work, part of the TIME project, about the predictive model of restenosis based coupling ABM and CFD at the ANSYS Simulation World (https://www.simulationworld.com/agenda/session/514899).
PhD Pills: presenting TIME!
Enjoy the 3-minute presentation of Anna Corti's PhD work, organized by the Department of Chemistry of Politecnico di Milano, at the link:
https://www.cmic.polimi.it/media/3633/phd-pills-anna-corti.mp4
TIME presented at ECMI 2021
During the ECMI Conference 2021, Monika Colombo presented her work, part of the TIME project, on the 3D modelling of drug-coated balloon treatment for diseased femoral arteries (https://ecmi2021.uni-wuppertal.de/).
New publication online!
Our new research product on the restenosis prediction based on hemodynamic descriptors is availble online at:
https://www.nature.com/articles/s41598-020-80681-8
Enjoy!
January 2021
November 2020
TIME wins at CAE conference!
Presented by our Anna Corti, TIME project wins one of the poster awards at the CAE conference 2020 (https://www.caeconference.com/). The poster is entitled "Patient-specific multiscale modeling of in-stent restenosis: integrating hemodynamics, gene expression and cellular dynamics" and gives insights on the multiscale modelling integrating cellular events, fluid dynamics and gene expression.
August 2020
August 2020
Anna Corti wins at VPH2020!
Our Anna Corti has been awarded at the VPH2020 conference (https://vph2020.sciencesconf.org/) with the best VPHi Student Award, for her presentation entitled "Towards a patient-specific multiscale framework of in-stent restenosis: integration of hemodynamics and gene expression with an agent-based model of cellular dynamics", within the TIME project.
OUR PROJECT
Funded by FONDAZIONE CARIPLO
We aim to develop a predictive systems biology model of vascular remodeling based on patient-specific data to better understand the underlying mechanisms of restenosis in peripheral arteries after endovascular treatment and to give indication on the interdependency of multiple factors, from molecular to tissue level, for this disease.
RESEARCH TOPICS
FEA
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Finite element simulations of self-expanding stent deployment in femoral arteries
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Quantification of tissue damage after angioplasty balloon expansion in atherosclerotic femoral arteries
CFD
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Moving-boundary computational fluid dynamics (CFD) simulations of femoral arteries undergoing lower-limb movement.
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CFD simulations of patient-specific stented superficial femoral arteries to investigate the impact of local hemodynamics on in-stent restenosis and its progression.
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CFD and mass transport simulations of drug-coated balloons for the treatment of atherosclerotic plaques in femoral arteries.
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Simulations of oxygen and low-density lipoprotein (LDL) transport in patient-specific superficial femoral artery models.
ABM
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Coupled CFD – agent-based model (ABM) of atherosclerosis in femoral arteries.
Coupled CFD and ABM of cellular dynamics to predict in-stent restenosis in patient-specific stented superficial femoral arteries. The systems biology model is able to integrate the local hemodynamic stimuli at the tissue level and the monocyte gene expression at the molecular level. -
Computational framework based on FEA, CFD simulations and ABM of cellular dynamics to simulate the restenosis process in superficial femoral artery models after endovascular treatment. The model is able to integrate multiple factors, including the tissue damage and the local hemodynamics at the tissue level, and the monocyte gene expression at the molecular level.
THE TEAM
PhD, Principal Investigator
PhD
PhD Candidate
Rodriguez Matas Jose Felix
Associate Professor
Antonini Luca
PhD Candidate
Gallo Diego
Associate Professor
Migliavacca Francesco
Full Professor
Bridio Sara
PhD Candidate
Pennati Giancarlo
Full Professor
Berceli Scott
MD
He Yong
PhD
Casarin Stefano
PhD
Garbey Marc
Full Professor
Rozowsky Jared M
PhD Candidate
MSc Students
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Mariagaia Cardinali, 2021 – present
("Modello multiscala di ristenosi in arterie femorali a seguito di angioplastica: impatto di danno e emodinamica locale") -
Claudia Isola, 2021 - present
("Modello multiscala di ristenosi in arterie femorali a seguito di angioplastica: impatto di danno e emodinamica locale") -
Federica Colombo, 2020 – 2021
(“Modello agent-based della risposta al danno di parete provocato dall’angioplastica in arterie femorali”) -
Andrea Colombo, 2020 -2021
(“Simulazione emodinamica di arterie femorali trattate con stent”) -
Giacomo Antognoli, 2020 -2021
(“Simulazione emodinamica di arterie femorali trattate con stent”) -
Tatiana Armillei, 2019 – 2021
(“Modello agent-based di aterosclerosi in arterie femorali”) -
Alessia Budini, 2019 - 2021
(“Modello agent-based di aterosclerosi in arterie femorali”) -
Federica Ninno, 2019-2020
(“Geometric and computational fluid dynamics analyses to investigate restenosis development in patient-specific stented superficial femoral arteries”)
PUBLICATIONS
2022
Monika Colombo, Anna Corti, Diego Gallo, Andrea Colombo, Giacomo Antognoli, Martina Bernini, Ciara McKenna, Scott Berceli, Ted Vaughan, Francesco Migliavacca, Claudio Chiastra
Computers in Biology and Medicine
2021
Anna Corti, Monika Colombo, Francesco Migliavacca, Josè Felix Rodriguez Matas, Stefano Casarin, Claudio Chiastra
Frontiers in Bioengineering and Biotechnology
3D modelling of drug-coated balloons for the treatment of calcified superficial femoral arteries
Monika Colombo, Anna Corti, Scott Berceli, Francesco Migliavacca, Sean McGinty, Claudio Chiastra
PLoS ONE
Monika Colombo, Yong He, Anna Corti, Diego Gallo, Federica Ninno, Stefano Casarin, Jared Rozowsky, Francesco Migliavacca,
Scott Berceli, Claudio Chiastra
Annals of Biomedical Engineering
Monika Colombo, Yong He, Anna Corti, Diego Gallo, Stefano Casarin, Jared Rozowsky, Francesco Migliavacca, Scott Berceli, Claudio Chiastra
Scientific Reports
2020
Impact of lower limb movement on the hemodynamics of femoropopliteal arteries: A computational study
Monika Colombo*, Giulia Luraghi*, Ludovica Cestariolo, Maddalena Ravasi, Anna Airoldi, Claudio Chiastra, Giancarlo Pennati
Medical Engineering and Physics
Anna Corti, Claudio Chiastra, Monika Colombo, Marc Garbey, Francesco Migliavacca, Stefano Casarin​
Computers in Biology and Medicine
Medical Engineering and Physics
2019
Anna Corti, Stefano Casarin, Claudio Chiastra, Monika Colombo, Francesco Migliavacca, Marc Garbey
Lecture Notes in Computer Science
ACCEPTED ABSTRACTS AT INTERNATIONAL CONFERENCES
2021
2020
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Corti A., Colombo M., Rozowsky J.M, Casarin S., He Y., Migliavacca F., Rodriguez Matas J.F., Berceli S., Chiastra C., “An in-silico study of in-stent restenosis: integrating mechano-biological factors and cellular dynamics in a patient-specific multiscale model”, ANSYS Simulation World 2021, April 20-21, 2021.
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Colombo M., Corti A., Berceli S., Migliavacca F., McGinty S., Chiastra C., "3D modelling of drug-coated balloons for diseased superficial femoral arteries", ECMI Virtual conference 2021, April 13-15, 2021.
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A. Corti, S. Casarin, J. Rozowsky, M. Colombo, Y. He, F. Migliavacca, J.F. Rodriguez Matas, S. Berceli, C. Chiastra, “Towards a patient-specific multiscale framework of in-stent restenosis: integration of hemodynamics and gene expression with an agent-based model of cellular dynamics”, Virtual Physiological Human Conference (VPH 2020), Paris (France), Online, August 24-28, 2020.
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Corti A., Chiastra C., Colombo M., Migliavacca F., Casarin S., “Computational modeling of atherosclerosis: sensitivity analysis towards a quantitative calibration”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020
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Corti A., Casarin S., Rozowsky J.M., Colombo C., He Y., Migliavacca F., Rodriguez Matas J., Berceli S., Chiastra C., “A multiscale computational framework of in-stent restenosis: linking gene dynamics and hemodynamics to an agent-based model of cellular dynamics”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020
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Colombo M., He Y., Corti A., Gallo D., Casarin S., Rozowsky J.M., Migliavacca F., Berceli S., Chiastra C., “In-stent restenosis in superficial femoral arteries: dynamic vessel remodeling and impact of local hemodynamics”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020
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Luraghi G., Colombo M., Chiastra C., Pennati G., “Impact of the lower limb movement on the hemodynamics of femoropopliteal arteries: a computational study”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019
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Corti A., Chiastra C., Colombo M., Garbey M., Migliavacca F., Casarin S. “A multiscale model of atherosclerotic plaque development in the femoral artery: coupling blood flow simulations with cellular dynamics in a CFD-ABM framework”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019
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Colombo M., Corti A., Luraghi L., Rodriguez Matas J.F., Migliavacca F., Pennati G., Chiastra C., “Femoral artery hemodynamics: state of the art of computational analyses and future trends”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019
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Colombo M., Bologna M., He Y., Garbey M., Rodriguez Matas J.F., Berceli S., Migliavacca F., Chiastra C., “Computational investigation of the relationship between hemodynamics and restenosis in stented femoral arteries”, IX Annual Meeting of the Italian Chapter of the European Society of Biomechanics (ESB-ITA), Bologna (Italy), September 30 - October 1, 2019
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Colombo M., Bologna M., He Y., Garbey M., Berceli S., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Reconstruction of patient-specific stented femoral artery models: from CT images to CFD analyses”, 25th congress of the European Society of Biomechanics, Wien (Austria), July 7-10, 2019
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Colombo M., Bologna M., He Y., Garbey M., Berceli S., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Analysis of the impact of local hemodynamics on restenosis in stented superficial femoral arteries”, 25th congress of the European Society of Biomechanics, Wien (Austria), July 7-10, 2019
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Corti A., Casarin S., Chiastra C., Colombo M., Migliavacca F., Garbey M., “A multiscale model of atherosclerotic plaque development: toward a coupling between agent-based model and CFD simulations”, International Conference on Computational Science, Faro, Algarve (Portugal), June 12-14, 2019
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Colombo M., Bologna M., Garbey M., Berceli S., He Y., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Patient-specific hemodynamic analysis of CT-derived stented superficial femoral arteries”, 14th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, Imperial College, London (United Kingdom), April 11-12, 2019
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Colombo M., Bologna B., Rodríguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Local hemodynamics of patient-specific diseased femoral arteries: role of the inflow boundary condition”, International CAE conference 2018, Vicenza (Italy), October 8-9, 2018
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Colombo M., Bologna M., Rodriguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Reconstruction of patient-specific femoral artery models for CFD applications: validation using 3D printed phantoms”, 3D Printing and Biomechanics, 2o Congresso IDBN - III Thematic Conference ESB-ITA, Pavia (Italy), September 5-7, 2018
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Colombo M., Bologna M., Rodriguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Validation of a reconstruction method of femoral artery models from computed tomography and application to in vivo cases”, Virtual Physiological Human Conference (VPH 2018), Zaragoza (Spain), September 5-7, 2018
2019
2018
