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TIME

from TIssue to Molecular mechanisms of restenosis

after peripheral Endovascular interventions

NEWS

April 2021

New publication online!

Find our new research product on the analysis of the restenosis progression in human superficial femoral arteries, availble online at: 

https://link.springer.com/article/10.1007/s10439-021-02776-1

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TIME presented at SimWorld

Anna Corti presented her work, part of the TIME project, about the predictive model of restenosis based coupling ABM and CFD at the ANSYS Simulation World (https://www.simulationworld.com/agenda/session/514899). 

PhD Pills: presenting TIME!

Enjoy the 3-minute presentation of Anna Corti's PhD work, organized by the Department of Chemistry of Politecnico di Milano, at the link: 
https://www.cmic.polimi.it/media/3633/phd-pills-anna-corti.mp4

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TIME presented at ECMI 2021

During the ECMI Conference 2021, Monika Colombo presented her work, part of the TIME project, on the 3D modelling of drug-coated balloon treatment for diseased femoral arteries (https://ecmi2021.uni-wuppertal.de/). 

New publication online!

Our new research product on the restenosis prediction based on hemodynamic descriptors is availble online at:

https://www.nature.com/articles/s41598-020-80681-8

Enjoy!

January 2021

November 2020

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TIME wins at CAE conference!

Presented by our Anna Corti, TIME project wins one of the poster awards at the CAE conference 2020 (https://www.caeconference.com/). The poster is entitled "Patient-specific multiscale modeling of in-stent restenosis: integrating hemodynamics, gene expression and cellular dynamics" and gives insights on the multiscale modelling integrating cellular events, fluid dynamics and gene expression.

August 2020

August 2020

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Anna Corti wins at VPH2020!

Our Anna Corti has been awarded at the VPH2020 conference (https://vph2020.sciencesconf.org/) with the best VPHi Student Award, for her presentation entitled "Towards a patient-specific multiscale framework of in-stent restenosis: integration of hemodynamics and gene expression with an agent-based model of cellular dynamics", within the TIME project.

 
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OUR PROJECT

Funded by FONDAZIONE CARIPLO

We aim to develop a predictive systems biology model of vascular remodeling based on patient-specific data to better understand the underlying mechanisms of restenosis in peripheral arteries after endovascular treatment and to give indication on the interdependency of multiple factors, from molecular to tissue level, for this disease.

 
 
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RESEARCH TOPICS

FEA
  • Finite element simulations of self-expanding stent deployment in femoral arteries

  • Quantification of tissue damage after angioplasty balloon expansion in atherosclerotic femoral arteries

CFD
  • Moving-boundary computational fluid dynamics (CFD) simulations of femoral arteries undergoing lower-limb movement.

  • CFD simulations of patient-specific stented superficial femoral arteries to investigate the impact of local hemodynamics on in-stent restenosis and its progression.

  • CFD and mass transport simulations of drug-coated balloons for the treatment of atherosclerotic plaques in femoral arteries.

  • Simulations of oxygen and low-density lipoprotein (LDL) transport in patient-specific superficial femoral artery models.

ABM
  • Coupled CFD – agent-based model (ABM) of atherosclerosis in femoral arteries.
    Coupled CFD and ABM of cellular dynamics to predict in-stent restenosis in patient-specific stented superficial femoral arteries. The systems biology model is able to integrate the local hemodynamic stimuli at the tissue level and the monocyte gene expression at the molecular level.

  • Computational framework based on FEA, CFD simulations and ABM of cellular dynamics to simulate the restenosis process in superficial femoral artery models after endovascular treatment. The model is able to integrate multiple factors, including the tissue damage and the local hemodynamics at the tissue level, and the monocyte gene expression at the molecular level.

 

THE TEAM

Chiastra Claudio

PhD, Principal Investigator

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Colombo Monika

PhD Candidate

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Corti Anna

PhD Candidate

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Rodriguez Matas Jose Felix

Associate Professor

Antonini Luca

PhD Candidate

Gallo Diego

Associate Professor

Migliavacca Francesco

Full Professor

Bridio Sara

PhD Candidate

Pennati Giancarlo

Full Professor

Berceli Scott

MD

He Yong

PhD

Casarin Stefano

PhD

Garbey Marc

Full Professor

Rozowsky Jared M

PhD Candidate

MSc Students
  • Mariagaia Cardinali, 2021 – present
    ("
    Modello multiscala di ristenosi in arterie femorali a seguito di angioplastica: impatto di danno e emodinamica locale")

  • Claudia Isola, 2021 - present
    ("Modello multiscala di ristenosi in arterie femorali a seguito di angioplastica: impatto di danno e emodinamica locale")

  • Federica Colombo, 2020 – 2021
    (“Modello agent-based della risposta al danno di parete provocato dall’angioplastica in arterie femorali”)

  • Andrea Colombo, 2020 -2021
    (“Simulazione emodinamica di arterie femorali trattate con stent”)

  • Giacomo Antognoli, 2020 -2021
    (“Simulazione emodinamica di arterie femorali trattate con stent”)

  • Tatiana Armillei, 2019 – 2021
    (“Modello agent-based di aterosclerosi in arterie femorali”)

  • Alessia Budini, 2019 - 2021
    (“Modello agent-based di aterosclerosi in arterie femorali”)

  • Federica Ninno, 2019-2020
    (“Geometric and computational fluid dynamics analyses to investigate restenosis development in patient-specific stented superficial femoral arteries”)

 

PUBLICATIONS

2021
2020
2019
ACCEPTED ABSTRACTS AT INTERNATIONAL CONFERENCES
2021
2020
  1. Corti A., Colombo M., Rozowsky J.M, Casarin S., He Y., Migliavacca F., Rodriguez Matas J.F., Berceli S., Chiastra C., “An in-silico study of in-stent restenosis: integrating mechano-biological factors and cellular dynamics in a patient-specific multiscale model”, ANSYS Simulation World 2021, April 20-21, 2021.

  2. Colombo M., Corti A., Berceli S., Migliavacca F., McGinty S., Chiastra C., "3D modelling of drug-coated balloons for diseased superficial femoral arteries", ECMI Virtual conference 2021, April 13-15, 2021.

     

  3. A. Corti, S. Casarin, J. Rozowsky, M. Colombo, Y. He, F. Migliavacca, J.F. Rodriguez Matas, S. Berceli, C. Chiastra, “Towards a patient-specific multiscale framework of in-stent restenosis: integration of hemodynamics and gene expression with an agent-based model of cellular dynamics”, Virtual Physiological Human Conference (VPH 2020), Paris (France), Online, August 24-28, 2020.

  4. Corti A., Chiastra C., Colombo M., Migliavacca F., Casarin S., “Computational modeling of atherosclerosis: sensitivity analysis towards a quantitative calibration”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020

  5. Corti A., Casarin S., Rozowsky J.M., Colombo C., He Y., Migliavacca F., Rodriguez Matas J., Berceli S., Chiastra C., “A multiscale computational framework of in-stent restenosis: linking gene dynamics and hemodynamics to an agent-based model of cellular dynamics”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020

  6. Colombo M., He Y., Corti A., Gallo D., Casarin S., Rozowsky J.M., Migliavacca F., Berceli S., Chiastra C., “In-stent restenosis in superficial femoral arteries: dynamic vessel remodeling and impact of local hemodynamics”, Summer Biomechanics, Bioengineering and Biotransport Virtual Conference, June 17-20, 2020


     

  7. Luraghi G., Colombo M., Chiastra C., Pennati G., “Impact of the lower limb movement on the hemodynamics of femoropopliteal arteries: a computational study”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019

  8. Corti A., Chiastra C., Colombo M., Garbey M., Migliavacca F., Casarin S. “A multiscale model of atherosclerotic plaque development in the femoral artery: coupling blood flow simulations with cellular dynamics in a CFD-ABM framework”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019

  9. Colombo M., Corti A., Luraghi L., Rodriguez Matas J.F., Migliavacca F., Pennati G., Chiastra C., “Femoral artery hemodynamics: state of the art of computational analyses and future trends”, 11th European Symposium on Vascular Biomaterials (ESVB 2019), Strasburg (France), October 17-19, 2019

  10. Colombo M., Bologna M., He Y., Garbey M., Rodriguez Matas J.F., Berceli S., Migliavacca F., Chiastra C., “Computational investigation of the relationship between hemodynamics and restenosis in stented femoral arteries”, IX Annual Meeting of the Italian Chapter of the European Society of Biomechanics (ESB-ITA), Bologna (Italy), September 30 - October 1, 2019

  11. Colombo M., Bologna M., He Y., Garbey M., Berceli S., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Reconstruction of patient-specific stented femoral artery models: from CT images to CFD analyses”, 25th congress of the European Society of Biomechanics, Wien (Austria), July 7-10, 2019

  12. Colombo M., Bologna M., He Y., Garbey M., Berceli S., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Analysis of the impact of local hemodynamics on restenosis in stented superficial femoral arteries”, 25th congress of the European Society of Biomechanics, Wien (Austria), July 7-10, 2019

  13. Corti A., Casarin S., Chiastra C., Colombo M., Migliavacca F., Garbey M., “A multiscale model of atherosclerotic plaque development: toward a coupling between agent-based model and CFD simulations”, International Conference on Computational Science, Faro, Algarve (Portugal), June 12-14, 2019

  14. Colombo M., Bologna M., Garbey M., Berceli S., He Y., Rodriguez Matas J.F., Migliavacca F., Chiastra C., “Patient-specific hemodynamic analysis of CT-derived stented superficial femoral arteries”, 14th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, Imperial College, London (United Kingdom), April 11-12, 2019


     

  15. Colombo M., Bologna B., Rodríguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Local hemodynamics of patient-specific diseased femoral arteries: role of the inflow boundary condition”, International CAE conference 2018, Vicenza (Italy), October 8-9, 2018

  16. Colombo M., Bologna M., Rodriguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Reconstruction of patient-specific femoral artery models for CFD applications: validation using 3D printed phantoms”, 3D Printing and Biomechanics, 2o Congresso IDBN - III Thematic Conference ESB-ITA, Pavia (Italy), September 5-7, 2018

  17. Colombo M., Bologna M., Rodriguez Matas J.F., Migliavacca F., Garbey M., Berceli S., Chiastra C., “Validation of a reconstruction method of femoral artery models from computed tomography and application to in vivo cases”, Virtual Physiological Human Conference (VPH 2018), Zaragoza (Spain), September 5-7, 2018

2019
2018
 
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